Glucoform® Tablets x 100 (Metformin Hydrochloride 500mg)

GLUCOFORM® TABLET
(METFORMIN HYDROCHLORIDE 500mg)

COMPOSITION
Glucoform® Tab 500mg contains Metformin Hydrochloride 500mg, an oral hypoglycaemic agent of the biguanide group.

PHARMACOLOGY
Glucoform® Tablet contains Metformin 500mg, a biguanide, which acts by:
(a) Direct stimulation of glycolysis in peripheral tissues, with increased glucose removal from blood
(b) Reduced hepatic gluconeogenesis
(c) Slowing of glucose absorption from the gastrointestinal tract (GIT)
(d) Reduction of plasma glucagons levels
(e) Increase insulin binding to insulin receptors

The blood glucose-lowering action does not depend on the presence of functioning pancreatic ß- cells. It only acts in the presence of endogenous insulin.

Glucoform® is the drug of choice in grossly obese patients in whom strict dieting has failed to control diabetes. It is also used when diabetes is inadequately controlled with sulphonylureas.

Hypoglycaemia is not a problem with Glucoform®; other advantages are the lower incidence of weight gain and lower plasma insulin concentration. It does not exert a hypoglycaemic action in non-diabetic subjects unless given in overdose. Glucoform® is rapidly absorbed from the gut, it is not protein-bound in the plasma neither is it metabolized to any degree by the liver and is excreted unchanged by the kidney within 24 hours. Its mean plasma half-life is short-about 2-3 hours. It often induces anorexia and diarrhoea. It is suited for obese diabetics.

INDICATIONS
Non-insulin dependent diabetes, especially in overweight patients not responding to diet alone or to diet plus treatment with a sulphonylurea.

CONTRA INDIACTIONS
Impaired renal or hepatic function, cardiovascular collapse, congestive heart failure (CHF), acute myocradia infarction (acute MI); diabetes mellitus complicated by acidosis, infection or gangrene, surgery, pregnancy, breast- feeding, alcoholism.

PRECAUTIONS
Monitor renal function regularly to reduce risk of lactic acidosis; stop therapy 2-3 days before surgery and clinical investigations involving the use of iodinated materials, condition which may cause dehydration or in patients suffering from serious infection of trauma.

KEEP OUT OF REACH OF CHILDREN

INTERACTIONS
• Alcohol- do not take alcohol when you are on metformin therapy.
• May decrease vitamin B12 and folic absorption.
• Cationic drugs e.g. Cimetidine, might reduce renal clearance of metformin
• Nifedipine enhances absorption of metformin.
• Co-administration with sulphonylurea may cause hypoglycaemia.

ADVERSE EFFECTS
Gastro-intestinal upset, fatigue, skin rashes, lactic acidosis.

ADVICE TO PATIENTS
Eat regularly, do not skip meals; carry quick source of sugar, avoid alcohol.

DOSAGE
Adult-500mg 8 hourly or 750mg 12 hourly with meals, up to a maximum of 3g daily if necessary.

STORAGE
Store in cool dry place, protect from light.

PRESENTATION
Glucoform® Tablet is presented in a pack containing 10 X 10 strips.

NAFDAC REGISTRATION NUMBER: 04-7120

Manufactured by:
DRUGFIELD PHARMACEUTICALS LIMITED
Lynson Chemical Avenue,
Km 38, Lagos-Abeokuta Expressway,
Sango-Otta, Nigeria