- About Drugfield
BIOCINE® (LINCOMYCIN HYDROCHLORIDE) Capsules
500mg, Syrup 250mg/5ml and injection 600mg/2ml
Each Biocine® capsule contains Lincomycin Hydrochloride equivalent to 500mg Lincomycin base. Each ml of the sterile solution contains Lincomycin Hydrochloride equivalent to 300mg/ml Lincomycin base in 2ml ampoules. Each 5ml (teaspoonful) Biocine® Syrup contains Lincomycin Hydrochloride equivalent to 250mg Lincomycin base.
Bone and joint infections including osteomyelitis and septic arthritis
Skin and soft tissue infections such as celllulitis, abscesses, furuncles, impetigo acne and wound infections.
Upper respiratory infections including tonsilitis, pharyngitis, otitis media, finufits, scarlet fever and as adjuvant therapy for diphtheria.
Lower respiratory infections such as acute and chronic bronchitis- and pneumonia.
Septicaemia and endocarditis
Usage in Neonates. Biocine® is well tolerated in neonates and no adverse effects were reported.
DOSAGE AND ADMINISTRATION
Biocine® capsules, Biocine® Steriles solution, Biocine® Syrup
|Adults||500mg three times daily||600mg (2ml) every 24 hours||600mg (2ml) to 1g every 8 to 12 hours. Administer in an infusion of 5% glucose in water or normal saline|
|Severe||500mg(or more) four times daily||600mg(2ml) every 12 hours|
|Children||30mg/kg/day in 3 to 4 equal doses||10mg/kg every 24 hours||
10 to 20mg/kg/day in two or three doses at 8 to 12 hour
intervals.Administer as infusion as for adults.
|Severe||60mg/kg/day in 3 or 4 equal doses||10mg/kg every 12 hours|
Biocine® should not be injected intravenously as a bolus. Intravenous doses are given on the basis of 1gm of Biocine® diluted in not less than 100ml of appropriate solution and infused over a period of not less than one hour.
|Biocine® Syrup (Children over one month of age)|
|Weight||Age||Dosage (1 teaspoonful equals 5ml)|
Birth - 1 yr
1 - 5 yrs
5 - 9 yrs
9 - 12 yrs
12 - 18 yrs
¼ teaspoonful four times a day
½ teaspoonful four times a day (Calculated as 30-60mg/kg/day)
1 teaspoonful three times a day
1 teaspoonful four times a day
2 teaspoonful three times a day
|Over 45kg||Over 18 yrs||2 teaspoonful four times a day|
For optimal absorption, It is recommended that nothing should be given by mouth except water for a period of one to two hours before and after oral administration of Biocine®
1. Skin mucous membrane: Pruritis, skin rashes, urticaria, vaginitis
2. Gastrointestinal - Nausea, vomiting, abdominal distress and persistent diarrhoea
3. Haematopoietic- Leucopenia, Neutropenia, agranulocytosis and thrombocytopenic purpura
4. Cardiovascular- instances of hypotension following parental administration have been reported especially after rapid administration.
5. Liver-Jaundice and abnormal liver function tests have been observed during Lincomycin therapy
Biocine® is contra-indicated in patients previously found sensitive to Lincomycin or Clindamycin.
Biocine® Capsules: Each capsule contains Lincomycin hydrochloride equivalent to 500mg Lincomycin base blister pack of 2X10's.
Biocine® Sterile Solution: Each ml contains Lincomycin hydrochloride equivalent to 300mg/ml Lincomycin base in 2ml ampoules.
Biocine® Syrup: Each 5ml (teaspoonful) contains Lincomycin hydrochloride equivalent to 250mg Lincomycin base in 60ml bottles.
NAFDAC REGISTRATION NUMBER:
Biocine® Capsules -04-5587
Biocine® Syrup 100ml, 250mg/5ml -04-7530
DRUGFIELD PHARMACEUTICALS LIMITED
Lynson Chemical Avenue,
KM 38, Lagos Abeokuta Expressway,
Sango Otta, Nigeria.